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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

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Abstract

Peptide– and protein–nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In this review, we focus on the key roles played by peptides and proteins in improving, controlling, and defining the performance of nanotechnologies. Within this framework, we provide a comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles. In doing so, we highlight the great advances made by the field, as well as the challenges still faced in achieving the clinical translation of peptide- and protein-functionalised nano-drug delivery vehicles, imaging species, and active therapeutics.

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The article was received on 16 Dec 2017 and first published on 26 Feb 2018


Article type: Review Article
DOI: 10.1039/C7CS00877E
Citation: Chem. Soc. Rev., 2018,47, 3574-3620
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    Joules Joules Women Joules Women Joules Joules Women Women Joules Women Women Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

    C. D. Spicer, C. Jumeaux, B. Gupta and M. M. Stevens, Chem. Soc. Rev., 2018,  47, 3574
    DOI: 10.1039/C7CS00877E

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